Prevalence of Resistant Genes among Thai Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates
Therdsak Prammananan, Dr. rer. biol. hum.
National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Ministry of Science and Technology, Thailand Science Park, Pathumthani 12120, Thailand.
Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.
Extract
Almost all mechanisms of resistance to anti-TB drugs are associated with chromosomal mutations either of drug targets, like resistance to RIF and FQs, or of drug activating enzymes, such as resistance to INH and PZA. No plasmid-mediated drug resistance has been reported in M. tuberculosis. The knowledge of resistance mechanisms can render not only the development of rapid diagnostic tests based on determining drug-resistant genes but also the idea for development of new anti-TB drugs. However, the prevalence of mutations has been shown to be different for some drugs depending on the geographic areas and incidence of MDR-TB. Such differences should ...
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