Division of Endocrinology and Metabolism, Department of Medicine, Department of Immunology, Division of Medical Molecular Biology, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
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Extract
Diabetes mellitus affects more than 150 million people worldwide, and this number is expected to double within the next two decades. The genetic susceptibility to the disease and an individual genetic signature remain incompletely understood. However, during the past decade, genetic analysis of DM and its complications have been extremely productive. Multiple genes have been identified especially through a series of genome-wide association studies (GWAS). It is of important that results from various genetic studies must be replicated in different populations in the validation of individual findings. Demonstration of functional modifications of the encoded variant proteins will also be an important ...
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